Tamoxifen Citrate tablets(Nolvadex)
- Manufactured by: HygeHGH Biopharm Co., Ltd.
- Country of origin: China
- Manufactured since: 2009 – Present
- Package :10mg/60pills/1box
- Price: $1.5 – $3 per IU
- Minimum Order:1 kits
- Storage:2–8 ℃ in (room temperature)
- Delivery: 5-15 days
- Source: shop-jintropin.com/shop/
Tamoxifen Tablet is a medicine that is used for the treatment of Metastatic Breast Cancer, Adjuvant Treatment Of Breast Cancer and other conditions.
Tamoxifen citrate tablets, a nonsteroidal antiestrogen, are for oral administration. Each tablet contains 10 mg or 20 mg Tamoxifen (equivalent to 15.2 mg or 30.4 mg, respectively, of Tamoxifen citrate, ).
Each tablet contains the following inactive ingredients: croscarmellose sodium, hypromellose, lactose (monohydrate), magnesium stearate, polyethylene glycol 400, povidone, corn starch, and titanium dioxide.
Tamoxifen Citrate tablets Indications (benefit & effect)
Functions & Traits
TAMOXIFEN CITRATE IS A SERM WITH BOTH ESTROGEN AGONIST AND ANTAGONIST PROPERTIES. AS AN ANTI-ESTROGEN, NOLVADEX FUNCTIONS BY BINDING TO THE ESTROGEN RECEPTORS IN THE PLACE OF ESTROGEN. THIS BINDING PREVENTS THE ESTROGEN HORMONE FROM PERFORMING ITS ACTION IN CERTAIN PARTS OF THE BODY, WHICH IS PRECISELY WHY IT’S BENEFICIAL TO BREAST CANCER PATIENTS. MANY FORMS OF BREAST CANCER ACTUALLY FEED OFF ESTROGEN WHEN IT ATTACHES TO THE RECEPTORS IN THE CHEST. BY PREVENTING THE ATTACHMENT IN SUCH RECEPTORS, THIS ALSO PROTECTS ANABOLIC STEROID USERS FROM GYNECOMASTIA, WHICH CAN BE CAUSED BY ANABOLIC STEROIDS.
While primarily viewed as an anti-estrogen, Nolvadex also has the ability to act as estrogen, specifically in the liver. This presents a benefit as estrogenic activity in the liver has been linked to healthier cholesterol levels. For the steroid user, this can be extremely beneficial as many anabolic steroids tend to have an adverse effect on cholesterol. More on this when we look at the direct effects of Nolvadex later on.
Although primarily an anti-estrogen, Nolvadex also possess strong testosterone stimulating characteristics. Nolvadex has the ability to block the negative feedback that is brought on by estrogen at the hypothalamus and pituitary. As a result, this stimulates an enhanced release by the pituitary of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH). Both LH and FSH are essential to natural testosterone production. Without LH and FSH, with an even stronger emphasis on LH, there is no natural testosterone production.
For the anabolic steroid user, the primary effect of Nolvadex on cycle is in the prevention of gynecomastia. Nolvadex does not appear to have a strong effect in preventing the other primary estrogenic effect in water retention, but this can often be controlled in other ways. As for gynecomastia protection, this can be enough for many men and should be your first choice if it can get the job done. If not, you will need an AI like Arimidex. However, AI’s can have a negative effect on cholesterol. Alone AI’s do not appear to have a strong, negative effect, but when coupled with an aromatizing steroid this effect appears to be exasperated. Cholesterol can be controlled with the use of an AI, but if it can get the job done a SERM like Nolvadex should be your first choice. As an added bonus, remember this SERM will have a positive impact on your cholesterol levels.
The final effect of Nolvadex represents the most valuable one for the anabolic steroid user. The use of anabolic steroids will suppress natural testosterone production. The rate of suppression will be dependent on the steroid(s) being used, but in most cases, it will be significant. Once the use of anabolic steroids comes to an end, assuming the individual did not suffer from a prior low testosterone condition and did not damage his Hypothalamic-Pituitary-Testicular-Axis (HPTA) through improper practices, natural testosterone production will begin again. This natural production will begin on its own, however, there is a problem. Once you come off cycle your natural testosterone levels will be extremely low and while production will begin again they will remain low for a very long time. It will take months and months for the body to fully recover its prior high natural testosterone levels. In fact, it could take up to a year or more depending on the harshness of the cycle and the individual’s general dispositions. This means the individual will be in a state of low testosterone for quite some time, and that can come with a host of bothersome symptoms. This condition can include all the symptoms associated with low testosterone, i.e. depression, lethargy, low libido, no appetite, etc. Further, with testosterone levels low, the individual may very well lose a lot of muscle tissue gained through steroid use as cortisol becomes the dominant hormone in the body.
Due to the low testosterone issues after a cycle of anabolic steroids, most men are encouraged to implement a PCT plan that includes Nolvadex post anabolic steroid use. Solid PCT plans often contain Nolvadex as well as the SERM Clomid and the powerful peptide hormone HCG (Human Chorionic Gonadotropin). By implementing this PCT plan, you will greatly stimulate natural testosterone production, speed up the recovery process and greatly protect your physique. Once the PCT plan comes to an end, contrary to popular belief your testosterone levels will not be resting at their normal high level state. Total recovery will still take a lot of time. However, a PCT plan that includes Nolvadex will ensure you have enough testosterone for proper bodily function while your levels continue to naturally rise.
There are many performance enhancing athletes that scoff at PCT plans, and there is a time to forgo them. If you’re only going to be off cycle for a short period of time, say 4-6 weeks or are cruising on a low testosterone dose between full blown cycles, there is no logical reason for a PCT plan. Such scenarios are very common in hardcore bodybuilding circles but they are not realistic for most anabolic steroid users. Most steroid users will take a fair amount of time off cycle, and in the name of health and wellbeing this is the best approach. If this is the case, there is no logical reason for forgoing PCT, and we can guarantee those that implement it will be far better off.
Tamoxifen Citrate tablets Side Effects
Get emergency medical help if you have signs of an allergic reaction to tamoxifen: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Tamoxifen can increase your risk of stroke or blood clots. Call your doctor at once if you have:
- signs of a stroke – sudden numbness or weakness, severe headache, slurred speech, problems with vision or balance;
- signs of a blood clot in the lung – chest pain, sudden cough or shortness of breath, dizziness, coughing up blood; or
- signs of a blood clot deep in the body – pain, swelling, or warmth in one leg.
- Also call your doctor at once if you have:
- unusual vaginal bleeding or discharge;
- blurred vision, eye pain or redness, seeing halos around lights;
- changes in your menstrual periods;
- pain or pressure in your pelvic area;
- a new breast lump;
- liver problems – nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
- high blood calcium – confusion, tiredness, nausea, vomiting, loss of appetite, constipation, increased thirst or urination, weight loss.
Common tamoxifen side effects may include:
- vaginal bleeding or discharge;
- hot flashes;
- swelling, weight gain;
- nausea; or
- mood changes.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
Tamoxifen Citrate tablets DOSAGE AND ADMINISTRATION
For patients with breast cancer, the recommended daily dose is 20-40 mg. Dosages greater than 20 mg per day should be given in divided doses (morning and evening).
In three single agent adjuvant studies in women, one 10 mg NOLVADEX (tamoxifen citrate) tablet was administered two (ECOG and NATO) or three (Toronto) times a day for two years. In the NSABP B-14 adjuvant study in women with node-negative breast cancer, one 10 mg NOLVADEX (tamoxifen citrate) tablet was given twice a day for at least 5 years. Results of the B-14 study suggest that continuation of therapy beyond five years does not provide additional benefit (see CLINICAL PHARMACOLOGY). In the EBCTCG 1995 overview, the reduction in recurrence and mortality was greater in those studies that used tamoxifen for about 5 years than in those that used tamoxifen for a shorter period of therapy. There was no indication that doses greater than 20 mg per day were more effective. Current data from clinical trials support 5 years of adjuvant NOLVADEX (tamoxifen citrate) therapy for patients with breast cancer.
Ductal Carcinoma in Situ (DCIS)
The recommended dose is NOLVADEX (tamoxifen citrate) 20 mg daily for 5 years.
Reduction in Breast Cancer Incidence in High Risk WomenThe recommended dose is NOLVADEX (tamoxifen citrate) 20 mg daily for 5 years. There are no data to support the use of NOLVADEX (tamoxifen citrate) other than for 5 years (See CLINICAL PHARMACOLOGY-Clinical Studies – Reduction in Breast Cancer Incidence in High Risk Women).
10 mg Tablets containing tamoxifen as the citrate in an amount equivalent to 10 mg of tamoxifen (round, biconvex, uncoated, white tablet identified with NOLVADEX (tamoxifen citrate) 600 debossed on one side and a cameo debossed on the other side) are supplied in bottles of 60 tablets. NDC 0310-0600-60.
20 mg Tablets containing tamoxifen as the citrate in an amount equivalent to 20 mg of tamoxifen (round, biconvex, uncoated, white tablet identified with NOLVADEX (tamoxifen citrate) 604 debossed on one side and a cameo debossed on the other side) are supplied in bottles of 30 tablets. NDC 0310-0604-30.
Store at controlled room temperature, 20-25°C (68-77°F) [see USP]. Dispense in a well-closed, light-resistant container.
Storage Of Tamoxifen Citrate tablets
Store at controlled room temperature, 20-25°C (68-77°F). Dispense in a well-closed, light-resistant container.
Tamoxifen Citrate tablets Warnings
Taking tamoxifen may increase your risk of uterine cancer, liver cancer, stroke, or a blood clot in the lung, which can be fatal.
Do not use tamoxifen if you are pregnant. It could harm the unborn baby. Use a barrier form of birth control (such as a condom or diaphragm with spermicide) while you are using this medication and for at least 2 months after your treatment ends. You should not use tamoxifen if you are allergic to it, if you have a history of blood clots in your veins or your lungs, or if you are taking a blood thinner such as warfarin (Coumadin).
Before using this medicine, tell your doctor if you have liver disease, high triglycerides (a type of fat in the blood), a history of cataract, or a history of stroke or blood clot. Also tell your doctor if you if you are receiving chemotherapy or radiation treatment.
If you are taking tamoxifen to reduce your risk of breast cancer, you may need to take your first dose while you are having a menstrual period. You may also need to have a pregnancy test before you start taking this medicine, to make sure you are not pregnant. Follow your doctor’s instructions.
To make sure this medication is not causing harmful effects, your doctor may want you to have mammograms and to perform routine breast self-exams on a regular basis. Your liver function may also need to be tested. Visit your doctor regularly.
Tamoxifen Citrate tablets(Nolvadex) review
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